Teaching

Undergraduate teaching

MBoC Cover art

Molecular Biology of the Cell cover

For all of the stage III material in my lectures, Alberts’ Molecular biology of the Cell is a great starting point. The (red) 5th Edition is fine for everything but th new (blue) 6th edition does contain the most up-to-date content and some of the images used in the handouts used are taken from this edition.

 

Advanced Cell Biology

Advances in Bioimaging

Advanced light microscopy techniques including imaging of protein dynamics using FRET and photobleaching, sheet plane imaging, super-resolution microscopy, and high content screening. Includes examples of imaging from single molecules to whole organisms.

 

The organisation of intracellular traffic – secretory pathway

Advanced concepts in vesicle formation: cargo selection, membrane deformation, budding and subsequent maturation of carriers. The COPII system and collagen secretion. Early secretory pathway trafficking in development and disease. Golgi structure, organization and function. Congenital disorders of glycosylation. Golgins and the specificity of vesicle tethering.

 

Microtubule motors

Microtubule motor composition, accessory subunits, recruitment of motors to cargo. Regulation of activity, processivity, cargo binding, and directionality of movement focussing on the dynein complex. Roles of microtubule motors in development and disease. Cilia, ciliogenesis and intraflagellar transport.

Mitosis and the eukaryotic cell division cycle

The cell division cycle, mitosis, checkpoints, the control of DNA replication, and APC/C. The mitotic spindle, centrosome duplication, and spindle motors.  Kinetochore capture, microtubule flux, chromosome segregation. Cytokinesis, contractile ring, role of the ESCRT complex, abscission.  Mitosis in a physiological context: asymmetric division, control of cell cycle by mitogens & DNA damage, growth versus proliferation.

 

 

Second year undergraduate teaching on microtubule cytoskeleton

First year teaching on core principles of developmental biology, biochemical mechanisms of development.

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