I evaluated the following article for F1000:
Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.
AK Dunsch, D Hammond, J Lloyd, L Schermelleh, U Gruneberg and FA Barr J Cell Biol. 2012 Sep 17; 198(6): 1039-54
PMID: 22965910 DOI: 10.1083/jcb.201202112
The thing that fascinates me the most about this is the possibility that dynein containing light chain-1 acts without dynactin…..hence the crap title for the post.
This paper is highly intriguing from a dynein motor perspective as it strongly suggests that, in mitosis, the binding of dynein light chain 1 (DYNLL1) and the major dynein regulator dynactin are mutually exclusive. The work details very clearly how the adaptor proteins CHICA and HMMR target dynein to the mitotic spindle. This serves to control spindle positioning in cells, at least in part through promoting dynein asymmetry. It will be fascinating to determine whether DYNLL1 and dynactin can bind to dynein at the same time in interphase cells; this would of course have major implications for those studying dynein and dynactin function.