F1000 evaluation

I have evaluated the following article for Faculty of 1000.

Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat.
Kung LF, Pagant S, Futai E, D’Arcangelo JG, Buchanan R, Dittmar JC, Reid RJ, Rothstein R, Hamamoto S, Snapp EL, Schekman R, Miller EA.
EMBO Journal
DOI 10.1038/emboj.2011.444
PMID 22157747

This is a very nice set of data that show convincingly that Sec16 impacts on the Sar1-GTPase cycle during COPII coat assembly at the endoplasmic reticulum (ER) membrane. There are considerable nuances within the data set likely to be of major interest to COPII aficionados but, overall, this work gives some key insight into the control of vesicle formation by the COPII coat. The [http://f1000.com/13567956#eval14951056 Jon Audhya] evaluation describes this paper perfectly.

Additional comment: I don’t post the evaluation from Jon Audhya here. Jon highlights how this paper provides core mechanistic insight into COPII-dependent secretion through coupling the function of Sec16 to that of Sar1. This provides another piece of the puzzle in our understanding of Sec16 function. Bottom line: it is an interesting paper for those of us in this area. Read it!

Liz Miller also has a very intriguing Science paper recently published which I will comment on here once I have had time to read it properly.